2. Signaling Pathways
  3. GPCR/G Protein
  4. RGS Protein
  5. RGS Protein Isoform
  6. RGS Protein Inhibitor

RGS Protein Inhibitor

RGS Protein Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-70075
    CCG-63808
    		Inhibitor 98.0%
    CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.
  • HY-175763
    Z55660043
    		Inhibitor
    Z55660043 is a Regulator of G protein signaling-14 (RGS14) inhibitor with an IC50 of 2.3  μM. Z55660043 selectively and non-covalently inhibits RGS14 GTPase-accelerating protein (GAP) activity without measurable cytotoxicity. Z55660043 can be used for central nervous system and metabolic disorders research.
  • HY-13509R
    CCG-50014 (Standard)
    		Inhibitor
    CCG-50014 (Standard) is the analytical standard of CCG-50014. This product is intended for research and analytical applications. CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.